The largest 4 star hotel in manchesterr r macdonald manchester hotel amp spa set in the heart ofr cottonopolis is manchesters largest four star hotel perfectlyr located if travelling by rail by road or on foot our eye catchingr expanse dominates the skyline all the way from piccadilly stationr to the mancunian way allowing for quick and easy access to andr from all the major motorwaysr r the team at our hotel in manchester is driven to deliver anr outstanding guest experience and has a