A mountain town like no other welcome to the hampton inn wilkesboro the hampton inn wilkesboro hotel is located on the corner of highway 268 and collegiate drive just minutes from the majestic blue ridge mountains of north carolina this wilkesboro hampton inn is within walking distance of the wilkes community college campus and a short drive to both historic wilkesboro and north wilkesboro downtown areas within 5 miles of the north carolina hampton inn wilkesboro you can dine at sagebrus