Conveniently located in the heart of beautiful central california the hampton inn suites san luis obispo can be accessed directly off of scenic hwy 101 and los osos valley rd with championship golf courses over 40 premium wineries surfing fishing and hiking the hampton inn suites san luis obispo makes a perfect destination for a family vacation or just a weekend getaway situated near cal poly university mission de tolosa and legendary hearst castle you are sure to leave with a mag