Your relaxing retreat near the great smoky mountains welcome to the hampton inn knoxville east tn the hampton inn knoxville east tennessee hotel is centrally located between the downtown knoxville tennessee business district and the beautiful great smoky mountains national park the possibilities are endless when you visit our friendly hampton inn knoxville east hotel visit river otters and red pandas at the world class knoxville zoo enjoy a day trip to the great smoky mountains splash i